Press Release
Methylglyoxal Identified as a Cause of Depression and Cognitive Decline – Published Research
2024.12.18 14:25- 작성자 관리자
- 조회 14
Mechanism of MGO-Induced Neurodegeneration and Inflammation Unveiled
MetaCen Therapeutics (CEO Myoung-Gyu Park) and the AGEs Society have revealed through experiments that methylglyoxal (MGO), a precursor to advanced glycation end-products (AGEs), induces depression-like behavior and cognitive decline. The study was recently published in the journal Biological Research.
Methylglyoxal (MGO) is a naturally occurring compound produced primarily during glucose metabolism. While it plays roles in various physiological processes, excessive accumulation can lead to cell damage and inflammation, posing harmful effects on the body.
According to the study, mice administered with MGO showed neurological changes and biochemical abnormalities in brain metabolism. Notably, MGO inhibited tryptophan metabolism, significantly reducing serotonin and dopamine levels. It also increased Alzheimer’s disease-related markers, promoted the accumulation of reactive oxygen species (ROS), and reduced NAD+ levels, triggering neurodegeneration and inflammatory responses. These changes could ultimately lead to brain dysfunction and the onset of neurodegenerative diseases.
The AGEs Society stated that they have dedicated years to glycotoxin-reducing research involving MGO and similar compounds, focusing on the prevention and improvement of neurological conditions such as depression, Alzheimer’s disease, and Parkinson’s disease. One of the key outcomes of this research is the launch of “AGEs Probiotic PLW,” a product that promotes both gut and brain health.
The association claims that this product contains components that inhibit harmful bacteria such as Proteus mirabilis, a known contributing factor to Parkinson’s disease, and directly reduce MGO levels.
Additionally, other products like “AGEs 365 V2” and “AGEs Silk Plus” are formulated with ingredients that promote the breakdown of MGO and GO (glyoxal)-derived glycotoxins. These products are available for purchase at member pharmacies of the AGEs Society.
Reporter: Hyekyeong Kang (khk@dailypharm.com)
Source: [Korea Pharmaceutical Association] (https://www.dailypharm.com)
MetaCen Therapeutics (CEO Myoung-Gyu Park) and the AGEs Society have revealed through experiments that methylglyoxal (MGO), a precursor to advanced glycation end-products (AGEs), induces depression-like behavior and cognitive decline. The study was recently published in the journal Biological Research.
Methylglyoxal (MGO) is a naturally occurring compound produced primarily during glucose metabolism. While it plays roles in various physiological processes, excessive accumulation can lead to cell damage and inflammation, posing harmful effects on the body.
According to the study, mice administered with MGO showed neurological changes and biochemical abnormalities in brain metabolism. Notably, MGO inhibited tryptophan metabolism, significantly reducing serotonin and dopamine levels. It also increased Alzheimer’s disease-related markers, promoted the accumulation of reactive oxygen species (ROS), and reduced NAD+ levels, triggering neurodegeneration and inflammatory responses. These changes could ultimately lead to brain dysfunction and the onset of neurodegenerative diseases.
The AGEs Society stated that they have dedicated years to glycotoxin-reducing research involving MGO and similar compounds, focusing on the prevention and improvement of neurological conditions such as depression, Alzheimer’s disease, and Parkinson’s disease. One of the key outcomes of this research is the launch of “AGEs Probiotic PLW,” a product that promotes both gut and brain health.
The association claims that this product contains components that inhibit harmful bacteria such as Proteus mirabilis, a known contributing factor to Parkinson’s disease, and directly reduce MGO levels.
Additionally, other products like “AGEs 365 V2” and “AGEs Silk Plus” are formulated with ingredients that promote the breakdown of MGO and GO (glyoxal)-derived glycotoxins. These products are available for purchase at member pharmacies of the AGEs Society.
Reporter: Hyekyeong Kang (khk@dailypharm.com)
Source: [Korea Pharmaceutical Association] (https://www.dailypharm.com)